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Polyamine oxidase and acrolein as novel biochemical markers for diagnosis of cerebral stroke

Therefore, the discovery of a strategy for 12-LOX inhibition with a drug regimen capable of sustained 12-LOX inhibition is important for the treatment of DN in future studies

5, when glucose is high inside a cell, most of that glucose is metabolized through glycolysis, going first to glucose-6 phosphate, then fructose-6 phosphate, and then on through the rest of the glycolytic pathway

5 Natural flavonoids as ferroptosis inhibitors for the therapy of CNS diseases Flavonoids are one of the largest classes of plant polyphenols, characterized by a C6-C3-C6 backbone consisting of three rings labeled as A, B, and C (Dias et al., 2021)

however, further investigations are required to confirm this hypothesis

In summary, the activation of microglia and astrocytes, and the subsequent release of pro-inflammatory cytokines and ROS, create an unfavorable environment for neuronal damage and death