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Advanced analytical procedures including LCMS screening, heavy metal analysis, endotoxin testing, and sterility verification are routinely performed across commonly studied compounds

TorresACillonizCNiedermanMSMenndezRChalmersJDWunderinkRGet al

Additionally, the interindividual variability in gut microbiota composition significantly influences polyphenol biotransformation into bioactive metabolites, complicating the prediction of therapeutic outcomes and impeding the standardization of treatments (Cardona et al