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Inhibition of MT1-MMP restores IR expression, improving insulin sensitivity and glucose tolerance in both aged mice and diabetic mouse models

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Intriguingly, this study showed that Syn 1103 with a fully exposed hydrophobic core exhibited much stronger binding affinity for BSA compared to Syn S129E and also inhibited Syn 1103 aggregation

10.1038/cdd.2010.142 26 BreenM

To overcome these limitations, Ma et al

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