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Always in rats, continuous light exposure led to diminished humoral responses and interleukin-2 (IL-2) secretion, as well as persistent disruption of circadian leukocyte rhythms and decreased number and activation of NK cells 90,91

2.2 Animals and treatment Male C57BL/6J mice, aged 68 weeks and weighing 1820 g, were obtained from Zhuhai BesTest Bio-Tech Co., Ltd

doi: 10.1111/jpi.12547 100 KadenaMKumagaiYVandenbonAMatsushimaHFukamachiHMarutaNet al

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Zinc chelators, such as prostaglandins, glutathione, pancreatic secretions, tripeptides, amino acids, and organic acids, can promote its absorption

This response aligns with previous findings in breast and melanoma cancer models, in which adipocyte-derived EVs, leptin, and fatty acids promote mitochondrial reprogramming and fatty acid oxidation in tumor cells [22,87,108,116]