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Gothelf, Y., Abramov, N., Harel, A

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These changes occurred before the increase in THDA levels, indicating that the loss of BDNF-TrkB signalling and upregulation of GSTO2 happens before the hyperdopaminergic state, as with the Trkb Penk -KO mice, supporting that GSTO2 increase is more likely a cause of neurodegeneration than a consequence of it

All these findings suggest the necessity of investigating the mechanisms of the protective effect of MSM, in order to develop strategies capable to increase performance in sport horses

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Deficiencies of other nutrients, including folate and B12, can also result in this condition