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Chronic hyperglycemia can induce circulating accumulation of lipid peroxidation products and impaired iron metabolic pathways, which results in the presence of a variety of free iron in plasma

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It causes the blood vessels to relax and regulates smooth muscle activity, epithelial cell secretion, and blood flow in the gastrointestinal tract

This contrasts with prior findings of our research group on the effects of disc degeneration on the range of motion of the thoracic and lumbar spine, where a strong decrease of the range of motion was already found for mildly degenerated discs of the thoracic spine 26 and where a gradual decrease in flexion/extension and lateral bending but a gradual increase of the range of motion was detected in axial rotation for the lumbar spine 27