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[DOI] [PMC free article] [PubMed] [Google Scholar] Zhou CF, Li XB, Sun H, Zhang B, Han YS, Jiang Y, Zhuang QL, Fang J, Wu GH

Riboceine has been demonstrated to enhance the synthesis of glutathione (GSH), a pivotal intracellular antioxidant that plays a substantial role in the neutralisation of free radicals and the protection of cells from oxidative stress ( 19 )

However, administration of siRNA lpa1 or AM095 (a lpa 1 inhibitor) mitigated MN injury and protected neurons in SOD1 G93A mice, which thus identifies a potential target in the treatment of ALS [172]